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Akari Therapeutics Shifts Focus to Oncology with Innovative ADC Technology

Reportable - Pharma and Biotech News July 23, 2025
By Reportable Staff
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Akari Therapeutics Shifts Focus to Oncology with Innovative ADC Technology

Summary

Akari Therapeutics, under new leadership, is pivoting towards oncology with a focus on developing Antibody Drug Conjugates (ADCs) that activate the immune system against cancer, aiming to overcome current treatment limitations.

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Akari Therapeutics has announced a strategic shift towards oncology, spearheaded by its newly appointed President and CEO, Abizer Gaslightwala. The company is focusing on the development of Antibody Drug Conjugates (ADCs) that incorporate a novel payload designed to activate the immune system against cancer. This innovative approach seeks to address the significant limitations of current ADC therapies, including tumor resistance and severe side effects.

Gaslightwala brings a wealth of experience from the biotechnology and pharmaceutical industry to Akari Therapeutics. He highlights the unique potential of the company's novel payload, which targets RNA splicing. This mechanism not only effectively kills cancer cells but also activates the immune system, offering a more durable treatment effect and reducing the chances of cancer developing resistance. This dual-action approach sets Akari's ADCs apart from existing therapies in the competitive oncology space.

Currently, Akari Therapeutics is advancing a lead ADC molecule through preclinical testing and is in the process of developing a second ADC with the same innovative payload. The company's strategy is centered on establishing its novel payload as the new standard for ADCs, leveraging its unique immuno-oncology properties to differentiate itself in the market. For more information on ADCs and their role in cancer treatment, visit https://www.cancer.gov.

Investors and stakeholders are encouraged to monitor upcoming data releases concerning the immune effects of Akari's RNA splicing inhibitor payload and the progress of its next ADC molecule, which targets a distinct cancer marker in solid tumors. Akari's leadership is optimistic about the potential of its ADC technology to achieve 'First-in-Class' and 'Best-in-Class' status, marking a significant advancement in cancer treatment options.

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